Vimentin, also known as fibroblast intermediate filament, is the major intermediate filament found in nonmuscle cells (Colvin et al., 1995 ). These cell types include fibroblast, endothelial cells, macrophages, melanocytes, Schwann cells, and lymphocytes. This is in contrast to keratin, which is the intermediate filament found in epithelial cells Vimentin intermediate filaments have been reported, however, in poorly differentiated rhabdomyosarcomas (Brockus and Myers, 2004). 2 Desmin. Desmin is the cytoskeletal component that holds myofibrils in place, and it has found use as a marker for canine leiomyomas and leiomyosarcomas (Sato et al., 2003) Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer,

Vimentin - an overview ScienceDirect Topic

Vimentin, a 57kDa intermediate filament protein, which is a class III intermediate filament protein and often found in mesenchymal cells in eukaryotes, or cells that contain a distinct nucleus, and predominately expressed in developing embryo and in cells. Vimentin intermediate filaments are in general present in mesenchymal cells Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival, and Her-2 status shows a valuable correlation with clinical parameters. Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs Vimentin staining confirms mesenchymal origin of some tumors; may be the only positive stain in certain cases and thus confirms that the tissue is capable of staining ( Am J Surg Pathol 2011;35:1722 ) May confirm mesenchymal origin but there are numerous exceptions, so relatively nonspecific. Helps distinguish clear cell renal cell carcinoma. VIM (Vimentin) is a Protein Coding gene. Diseases associated with VIM include Cataract 30, Multiple Types and Cataract 30.Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and DNA Damage.Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding

Vimentin IFs form close associations with the lipid droplets that are characteristic of adipose and steroidogenic cells. There is good evidence that changes in vimentin expression or organization can alter the metabolism of specific lipid components in cultured preadipose and adrenal cell lines. How Vimentin was observed in duct and alpha cells of mouse developing pancreas. Vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system. These results define vimentin N-terminal phosphorylation and fiber reorganization as a target of chemokine-dependent PI3Kgamma signaling in leukocytes Furthermore, autoantibodies against vimentin or citrullinated vimentin have been found to be involved in the pathogenesis of a variety of autoimmune diseases, including systemic lupus. Vimentin is a Type III intermediate filament that is primarily found in mesenchymal cells. Initially, it was assumed that the IFs served purely as a structural entity to give cells their shape and maintain their integrity. Over the past two decades, numerous roles and functions of the vimentin protein have been uncovered such as cellular. Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. By similarity

ビメンチン(英: vimentin )は、間葉系細胞に特有の中間径フィラメント(英: intermediate filament )である。. ビメンチンは結合組織を構成する線維芽細胞、血管内皮細胞、平滑筋細胞、横紋筋細胞、骨・軟骨細胞、神経鞘細胞など多様な細胞に分布する主要な細胞骨格蛋白である Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development

  1. and GFAP (1). Vimentin is the main intermediate filament protein in mesenchymal cells, and therefore is of value in the differential diagnosis of undifferentiated neoplasms.
  2. , keratin, neurofilaments or glial filaments. Shows wide cross-reactivity among mammalian species using various immunolabeling techniques
  3. Vimentin antibody detects vimentin, a type III intermediate filament protein with a predicted molecular weight of 54 kDa. Vimentin is highly expressed in cells of mesodermal origin as well as in some ectodermal cells, and is often used as a marker of mesenchymal stem cells
  4. VIM, vimentin Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog VIM, vimentin. Links HGNC:12692. NCBI Gene ID: 7431. neXtProt AC: NX_P08670. UniProt: P08670. Chr Location 10p13.
  5. Vimentin is a type III intermediate filament protein that anchors and supports organelles within the cytosol of mesenchymal cells. Expression of vimentin is upregulated during epithelial to mesenchymal transition ( EMT ), a process that occurs during neural development, wound healing, and cancer metastasis. Due to its diverse role within the.
  6. ant and pulverulent cataract
  7. 波形蛋白(Vimentin),或譯作波形纖維蛋白 ,是細胞裡中間絲這類蛋白質的其中一種,為人類結締組織細胞的特徵之一,於間葉細胞及其衍生細胞例如纖維母細胞中可見 。 中間絲是真核生物 細胞的重要結構性特徵。 它們與微管及肌動蛋白微細絲,組成並且合稱為細胞骨架

Vimentin in cancer and its potential as a molecular target

193060 - VIMENTIN; VIM - VIM Using cDNA clones of the VIM gene prepared from hamster lens mRNA, Quax et al. (1985) demonstrated that a single-copy gene encodes vimentin in man and that in man-rodent hybrid cells the gene segregates with human chromosome 10. Ferrari et al. (1987) showed by Southern blot analysis of DNA from somatic cell hybrids and by in situ chromosome hybridization that there. Vimentin: Products. Vimentin belongs to the intermediate filament family. It is highly expressed in mesenchymal cells and has been used as a specific mesenchymal marker. Show More. Vimentin has 19 results in Products. Sort by Vimentin, a 57 kD protein that is an intermediate filament is reported to be expressed in most cells of mesenchymal origin, including fibroblasts, endothelial cells, smooth muscle, melanocytes as well as T and B lymphocytes. Disclaime Examples of how to use vimentin in a sentence from the Cambridge Dictionary Lab

What is Vimentin? - Creative Diagnostic

vimentin-type intermediate filament associated coiled-coil protein-NM_001017921.3: s53340 details, s53340 search: Human: vimentin-type intermediate filament associated coiled-coil protein-NM_001017921.3: This page works best with JavaScript enabled! Assay ID 1301 Vimentin, which is a novel NF-κB regulator, is the primary receptor for the major Escherichia coli K1 virulence factor IbeA that contributes to the pathogenesis of neonatal bacterial sepsis and meningitis (NSM). We have previously shown that IbeA-induced NF-κB signaling through its primary receptor vimentin as well as its co-receptor PTB. Vimentin antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC), CoImmunoprecipitation (IP),Enzyme-linked Immunosorbent Assay (ELISA) applications. This antibody reacts with human, mouse, rat samples. Cat.No. 10366-1-AP. KD/KO Validated الفيمنتين (بالإنجليزية: Vimentin)‏ عبارة عن نوع من أنواع البروتينات الخيطية المتوسطية (بالإنجليزية: intermediate filament protein)‏ المكونة لهيكل الخلية، وتبلغ الكتلة الجزيئية للفيمنتين البشري 53.689 دالتون، ويوجد الفيمنتين عادةً في.

Vimentin is a ubiquitous intermediate filament protein often expressed in very large amounts in tissues requiring structural integrity. In spite of this, the VIM gene is under developmental control. Vimentin is often used as a biomarker of developmental transitions. Vimentin has numerous sits of post translational modification and regulation SANTA CRUZ BIOTECHNOLOGY, INC. Vimentin (V9): sc-6260 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com BACKGROUND Cytoskeletal intermediate filaments (IFs) constitute a diverse group of protein Detection of autoantibodies against mutated citrullinated vimentin is part of rheumatoid arthritis (RA) diagnostics, especially in sera negative for rheumatoid factor (RF negative sera). Anti-MCV antibodies are a member of the ACPA family, a group of the so-called antibodies to citrullinated protein/peptide antigens.. Rheumatoid arthritis is an autoimmune disorder

Vimentin-disrupted Tregs are superior in suppressing alloantigen-specific T cell priming in GVHD. Since inhibition of Tcon priming is a critical Treg-suppressive mechanism , we hypothesized that augmented GVHD inhibition after vimentin disruption by AEB701 or vimentin siRNA may be due to enhanced suppression of Tcon activation Vimentin is a widely expressed and highly conserved 54 kD protein that is constitutively expressed in mesenchymal cells, endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes 1,2. Vimentin is used as a marker of mesenchymal cells to distinguish them from epithelial cells 3

Figures and data in Highly multiplexed immunofluorescence

7431 - Gene ResultVIM vimentin [ (human)

VIM - Vimentin - Homo sapiens (Human) - VIM gene & protei

Vimentin Antibody (E-5) is a mouse monoclonal IgG 1 κ, cited in 126 publications, provided at 200 µg/ml. specific for an epitope mapping between amino acids 419-438 near the C-terminus of Vimentin of human origin. Anti-Vimentin Antibody (E-5) is recommended for detection of Vimentin of mouse, rat and human origin by WB, IP, IF, IHC (P) and. Vimentin is a 57 kDa intermediate filament protein which forms part of the cytoskeleton of vertebrate cells and is characteristically found in cells of mesenchymal origin. The coexpression of intermediate filaments, particularly vimentin and cytokeratin, has been demonstrated in a variety of normal cells/tissues and in neoplastic lesions, necessitating the use of antibodies against other types. Vimentin is present in nasal and lung epithelial cells, and it may also be present in the extracellular space of the lungs and other tissues. Using an anti-vimentin antibody and staining, the. Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al.MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Pathology Outlines - Vimenti

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development As vimentin is regulated at the transcriptional level [19, 32], we also analysed the expression profile of vimentin mRNA during adult erythropoiesis.Transcripts were detected in early erythroid cells, but expression then ceased (Fig. 1e), temporally coinciding with differentiation of pro-erythroblasts to basophilic erythroblasts. Expression of vimentin in erythroid cells differentiated from. Vimentin, a 57 kDa protein, is a type III intermediate filament, expressed in cells of mesenchymal origin. 13 It is typically considered to be an epithelial-mesenchymal transition (EMT) marker. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms. Description Vimentin Human Recombinant produced in E.coli cells is a single non-glycosylated protein containing 465 amino acids chain and having a molecular mass of 53.5kDa

Other E. coli strains can interact with vimentin on the host cell surface, in particular adherent-invasive E. coli strains (AIEC) involved in inflammatory bowel diseases [9,10].Vimentin acts as a surface-attached receptor of AIEC. In this context, it was also shown that vimentin acts as a Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)-interacting protein, an. Vimentin is the main intermediate filament protein in mesenchymal cells. Vimentin antibody shows no cross-reactivity with other closely related intermediate filament proteins such as Desmin and GFAP. Vimentin may be useful as an epithelial-mesenchymal transition (EMT) marker, giving an indication of tumor progression and potential for metastasis and is of value in the differential diagnosis of.

Vimentin is an intermediate filament protein with diverse roles in health and disease far beyond its structural functions. Exosomes or small extracellular vesicles (sEVs) are key mediators for intercellular communication, contributing to tissue homeostasis and the progression of various diseases, especially the metastasis of cancers. In this study, we evaluated a novel vimentin-binding. Vimentin, VIME_PIG. UniProt Code History. F1RWB8, F1RWC0, P02543. Gene Synonyms. VIM. 418 citations have been found for this product A First Case Report of Orbital Extra-Adrenal Paraganglioma in Cat. View PDF. In Veterinary Sciences on 14 May 2021 by Leonardi, L., Rizac, R. I., et al.. Pulmonary stromal expansion and intra-alveolar coagulation. Sills E, Doan T, Mock R, Dixson G, Rohlfing M. Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. Diagn Pathol. 2006;1:28 pubme Vimentin was detected in 69 out of 113 ccRCC tissues and significant associations were observed between the positive expressions of Vimentin and clinical stage, pathological grade, and metastasis (all P<0.001) (Figure 6(b)). However, both of VM and high expression of Vimentin did not show positive association with sex, age, or location (all P>0. Vimentin. Vimentin is a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions

VIM Gene - GeneCards VIME Protein VIME Antibod

Vimentin helps maintain the lipid composition of cellular membranes, and caspase cleavage of Vimentin is a key event in apoptosis (8, 12). Phosphorylation promotes secretion of Vimentin by TNF-alpha -stimulated macrophages (13). Extracellular Vimentin has been shown to associate with several microbes, and appears to promote an antimicrobial. ihcDirect ® Vimentin is a 57-60 kDa intermediate filament protein found in a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells and fibroblasts. ihcDirect Vimentin is a rabbit monoclonal (R289) assay that has value in the differential diagnosis of undifferentiated neoplasms including melanoma, lymphoma and. Provided below are ELISA kits targeting vimentin, a human protein encoded by VIM. This protein is 466 amino acids long, with a mass of 53.7 kDa, and is a member of the Intermediate filament family. This is reported to be a cytoplasmic and nuclear protein. There is a noted implication in Cataract 30, multiple types Vimentin Antibodies. Vimentin is a type III intermediate filament protein that plays an essential role in cytoskeletal function and is largely expressed by mesenchymal cells. Human vimentin monomer protein is 466 amino acids in length with theoretical molecular weight of ~54 kDa. We offer multiple 5-star rated antibodies to detect Vimentin that. The potential for targeting vimentin in cancer treatment and the development of drugs targeting vimentin will be reviewed. Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing.

Vimentin and lipid metabolism - PubMe

Malignant melanoma of the conjunctiva metastasising to the

22352 - Gene ResultVim vimentin [ (house mouse)

Video: Role of vimentin in modulating immune cell apoptosis and


Vimentin SpringerLin

VIM - Vimentin - Bos taurus (Bovine) - VIM gene & protei

  1. Vimentin is an intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it.
  2. vimentin (plural vimentins) (biochemistry) Any of a group of polypeptides that polymerize to form filaments in the cytoskeleton. Derived terms . phosphovimentin; Translations . any of a group of polypeptides that polymerize to form filaments in the cytoskeleton
  3. Vimentin is the major intermediate filament in a variety of mesenchymal cells, incl. endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian granulosa cells. Found in all types of sarcomas and lymphomas
  4. The Spike protein from SARS-CoV-2 mediates docking of the virus onto cells and contributes to viral invasion. Several cellular receptors are involved in SARS-CoV-2 Spike docking at the cell surface, including ACE2 and neuropilin. The intermediate filament protein vimentin has been reported to be present at the surface of certain cells and act as a co-receptor for several viruses; furthermore.

Vimentin expression in bone marrow is specific to stromal cells , which include MSCs. Therefore, separation and enrichment of MSCs from bone marrow cells can be achieved by exploiting vimentin expression. Vimentin plays an important cytoplasmic role in maintaining cell architecture and positioning organelles Vimentin (VIM) ist ein Typ 3-Intermediärfilament aus der Gruppe der Desmine und damit ein Element des Zytoskeletts der Wirbeltiere.Die Molekülmasse humanen Vimentins beträgt 53.689 Dalton.Es kommt im Zytoplasma (teilweise auch im Nucleolus) aller Zellen mesenchymaler Herkunft (z. B. Fibroblasten, Endothelzellen, glatte Muskelzellen) vor.. Über die genaue Funktion von Vimentin ist wenig. Test Includes: Measures IgG antibodies to mutated citrullinated vimentin (MCV). Logistics Test Indications: Avise MCV is a useful adjunct to traditional clinical and laboratory methods for diagnosis of RA, offering a high level of diagnostic accuracy and correlation to RA disease progression. Avise MCV measures autoantibodie

Vimentinとは? ビメンチン(Vimentin/VIM)は、 中間径フィラメント ファミリーに属します。 ビメンチンは、中間径フィラメントクラスIIIに属し、種々の非上皮系細胞、 特に間葉系細胞で発現します。 ビメンチンは、細胞質の構造を安定化するために重要な働きをします Vimentin at the center of epithelial-to-mesenchymal transition (EMT). Vimentin levels are positively associated with a loss of epithelial traits (green) and a gain of a pro-migratory mesenchymal phenotype (red). Vimentin expression is regulated by transcription factors Twist, Snail, Zeb1 and Slug, which are induced by TGF-β signaling Recombinant vimentin was citrullinated or carbamylated as previously described.7, 8 For the acetylated isoform, albumin was conjugated with the acetylated vimentin peptide as recombinant vimentin is not stable after treatment with acetylation reagents.21 Unmodified and modified vimentin proteins were separated by SDS-PAGE, transferred to.

ビメンチン - Wikipedi

Wimentyna (ang. vimentin) - białko cytoszkieletu eukariontów tworzące filamenty pośrednie typu III. U człowieka kodowane jest przez gen VIM w locus 10p13. Cytrulinowanej formie wimentyny przypisuje się rolę autoantygenu mogącego odgrywać rolę w patogenezie reumatoidalnego zapalenia stawów, a ocena ilościowa autoprzeciwciał przeciw cytrulinowanej wimentynie bywa stosowana. Abstract This paper examines both the anatomical changes in the distribution of vimentin intermediate filament protein and the biochemical changes in vimentin and its degradative enzyme during post..

Anti-Vimentin Antibodies Invitroge

Home Vimentin exhibits the following properties. 1 Divisibility 2 Comparability 3 Connectivity 4 Disturbability 5 Reorderability 6 Substitutability 7 Satisfiability 8 See also 9 References Can Vimentin exhibit divisibility? Yes. Vimentin exhibits divisibility. Vimentin can be divided into things.. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions

Moreover, SIX1 enhanced Vimentin expression in the transcriptional level through directly binding to the promoter domain of Vimentin, thereby promoting cell migration and invasion. In addition, miR-1306-3p was down-regulated and negatively correlated with pathological features and poor prognosis in gastric cancer Vimentin phosphorylation regulates vimentin dynamics 42-45 and ser56 phosphorylation is associated with cell motility signaling pathways. 40, 46 Specifically, vimentin ser56 phosphorylation inversely regulates PAK activation and is critical for vimentin filament spatial rearrangement elicited by agonists. 40 WFA induced dose-dependent vimentin. Reducing either vimentin levels via small interfering RNA interference or the expression of α 6 and β 1 integrins by the addition of blocking antibodies, reorganized the M12 subline into forming polarized acini. The loss of vimentin significantly reduced M12-Vim tumor growth when assessed by s.c. injection in athymic mice Human vimentin is a 53,521 dalton protein (466 amino acids) expressed in many cell types of mesodermal origin, and is one of the intermediate filament types that form the cytoskeleton. In the embryonic nervous system, however, vimentin is expressed by migrating neural crest cells forming the PNS, and by neural stem cells of the CNS Furthermore, vimentin is the target gene of miR-146a involved in ESCC tumorigenesis. MiR-146a suppressed cell proliferation, migration and invasion of CE81FN+ cells through the inhibition of vimentin expression, as confirmed by real-time PCR, Western blotting and Transwell™ assay

Translations in context of vimentin in English-French from Reverso Context: The invention relates to a transgenic non-human animal containing null alleles of GFAP and vimentin vimentin: ( vī-men'tin ), [MIM*193060] The major polypeptide that copolymerizes with other subunits to form the intermediate filament cytoskeleton of mesenchymal cells; may have a role in maintaining the internal organization of certain cells. See also: desmins Vimentin is a member of the intermediate filament protein family. Intermediate filaments are an important structural feature of eukaryotic cells. They, along with microtubules and actin microfilaments, make up the cytoskeleton. Despite the fact that most intermediate filaments exist as stable str..

Vimentin Rabbit Antibody - Biocare Medica

Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular marker. However, the importance of vimentin in the pathogenesis of HCC mediated by HBX has not been well determined. The expression of vimentin induced by HBX, and the role of LIM and SH3. Vimentin Antibody 可检测内源水平的总人波形蛋白。 来源/纯化 使用与人波形蛋白的 Ala61 周围的残基相对应的合成肽,对动物进行免疫接种来产生多克隆抗体

Sertoli cells (SCs) in the testes provide physical and nutritional support to germ cells. The vimentin cytoskeleton in SCs is disrupted by dibutyl phthalate (DBP), which leads to SCs dysfunction. In a previous study, we found that peroxisome proliferator-activated receptor alpha (PPAR α ) influenced the distribution of vimentin by affecting its phosphorylation in DBP-exposed SCs Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006) Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 Vimentin, a type III intermediate filament (IF) protein, is a major cytoskeletal component of motile mesenchymal cells, including fibroblasts, macrophages, and metastatic tumor cells of epithelial origin. Vimentin, like other cytoskeletal IF, forms a complex network that circumscribes the nucleus and radiates toward the cell periphery Thus, besides the vimentin the only two good markers that went though quality control will be alfa-SMA (myfibroblast/smooth muscle cell marker) and ER-TR7 (fibroblast marker). Diffieculty is that.

Mutant E-cadherin Breast Cancer Cells Do Not Display

The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins, which are the building blocks of highly ordered, dynamic, and cell type-specific fiber networks.Vimentin is a multi-functional 466 amino acid protein with a high degree of evolutionary conservation among vertebrates. Vim −/− mice, though viable, exhibit systemic defects related to development and wound. Human vimentin 10. Here we present the crystal structure of human vimentin fragment including residues 261-335 i.e. approximately the first half of coil 2. (Recombinant fragment within Human Vimentin (internal sequence). (The gene encoding human vimentin is located on the short arm of chromosome 10. (ihcworld.com)A GFP-vimentin construct was made by fusing GFP to the NH 2 -terminus of human. Anti-vimentin (ab92547) staining in adult mouse brain (the dentate gyrus region of the hippocampus) using immunohistochemistry (formaldehyde-fixed, paraffin-embedded sections). Heat-mediated antigen retrieval was carried out using citric acid. Samples were incubated with primary antibody (1/2000) for two hours at room temperature

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